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UnsubSafe is a proactive and intelligent anti-spam technology that consults a centralized database of online e-mail marketers reputations to make sure your unsubscribe request will be honored.

Email Automation Software Sends Personalized Bulk Email to Your Mailing Lists, Automatically Responds to Incoming Messages, Processes Your Subscribe and Unsubscribe Requests, and Cleans and Manages Your Lists

These scripts combine with Auto FollowUp. AFU allows people to subscribe to the autoresponder by email, but this collection contains a script that will actually answer an email! It will respond to email subscribe and unsubscribe requests.

Advanced Maillist Manager (AMM) is designed to process incoming messages that contain subscribe/unsubscribe/etc requests.

It automates the process of handling subscribe and unsubscribe requests to mailing lists for bulk email marketers. It will also process all of your bounced messages. Can send email confirmations for subscribe/unsubscribe requests.

Process your inbound email for confirmed opt-in list management, using simple yet powerful rules and tasks for sending auto replies, redirect messages. Automatically delete matched emails from your inbox, redirect the rest for you to read. Freeware.

With Mailing Master you can automate your mailings and your subscribe/unsubscribe lists and send each of your recipients an individual e-mail. The tool is perfect for newsletters, product upgrade announcements, support note or business notices.

Atomic Subscription Manager is a mailing list management utility. Once installed, this program automatically handles all user requests to subscribe/unsubscribe to/from the mailing list. The number of lists that can be maintained is not limited.

Manage subscription or unsubscription by email subject. GoMail Subscription Manager works seemlessly within Microsoft Outlook2000/2002 as a toolbar. It lets you monitor the InBox for particular subject line and automatically save/remove the sender.